Recurrent bronchospasm a middle age man

46 year old male presented for follow up to the outpatient clinic because of severe flu-like, asthmatic symptoms. The patient is concerned that in recent times, during the last year, he has been battling recurrent repiratory infections. He now "remembers" that as a child he used to suffer form episodes of bronchospsm and shortness of breath with exercise. He is now susceptible to just anything in the environment. His airways are very hypersensitive. What are you thinking about in your diagnositc approach and therapy with this otherwise healthy and corpulent man?